Research

Judith is currently a post-doctoral scientist in the Osten lab at Cold Spring Harbor Laboratory. For more information regarding her current work, please contact Judy directly from the contact page.

Doctoral Thesis:

Nanoscale Synapse Imaging and Whole Brain Neuronal Tracing  with Super Resolution Oblique Light Sheet Microscopy. PhD defended on April 28th, 2020. PI and Mentor: Dr. Pavel Osten, Cold Spring Harbor Laboratory

Graduate Work:

  • “Super-Resolution Oblique Light Sheet Microscopy for Meso- and Nanoscale Mapping of Brain Structure”. Judith Mizrachi, Arun Narasimhan, Xiaoli Qi, Rhonda Drewes, Ramesh Palaniswamy, Kannan Umadevi Venkataraju, Dinu F. Albeanu, and Pavel Osten. Abstract accepted by Nature 12/2019. Full paper to be submitted 04/2020.
  • “A High Resolution Whole Brain Imaging Using Oblique Light Sheet Tomography”. Arun Narasimhan, Kannan Umadevi Venkataraju, Judith Mizrachi Dinu F. Albeanu, Pavel Osten. Published in Bioarxiv., Paper to be Submitted.
  • “Oblique light-sheet tomography: fast and high resolution volumetric imaging of mouse brains”. Arun Narasimhan, Kannan Umadevi Venkataraju, Judith Mizrachi, Dinu F. Albeanu, Pavel Osten.  Published in Bioarxiv. Abstract accepted by Nature 11/2019. Full paper to be submitted 04/2020.
  • “System and Method for Light Sheet Microscope and Clearing for Tracing”. Inventors: A. Narasimhan, J. Mizrachi, K. Umadevi Venkataraju, D. Albeanu, P. Osten. U.S. Patent
  • “Brainwide atlas of cortical pyramidal neuron morphology”. Arun Narasimhan1, Corey Elowsky1, Jason Palmer1, Kannan Umadevi Venkataraju1, Judith Mizrachi1, Ramesh Palaniswamy1, James Gornet2, Uygar Sumbul3, Nicholas Turner4, H. Sebastian Seung4, Dinu F. Albeanu1 and Pavel Osten1. to be submitted to Cell, summer 2020.
Grant Applications:
  • “Super-resolution oblique light-sheet tomography for long-range tracing and local synapse mapping of neuronal cell types in the mouse brain” R01 NIH application. Impact Score: 30.
  • “Simultaneous Synapse Imaging and Whole Brain Neural Tracing with 3D Super-resolution Oblique Light Sheet Microscopy” F31 NRSA Application. Impact Score: 20.

Select Presentations

  • “Super Resolution Oblique Light Sheet Microscopy” J. Mizrachi, A. Narasimhan, Albeanu, P, P. Osten. Cold Spring Harbor Laboratory, Society for Neuroscience Annual Meeting, Symposium Talk, October 2019, Chicago, IL
  • “Super-resolution Oblique Light Sheet Microscopy”. J. Mizrachi, A. Narasimhan, K. Umadevi Venkataraju, S. Jia, P. Osten. Cold Spring Harbor Laboratory, Graduate Student Symposium Talk. Awarded 1st Place, Best Talk.
  • “Deconvolution and Image Processing for Oblique Light Sheet Tomography” J. Mizrachi, A. Narasimhan, K. UmadeviVenkataraju, P. Osten. BRAIN Initiative Annual Investigators Meeting Poster Session, April 2019, Washington D.C.
  • “Improved Deconvolution and Image Processing for Oblique Light Sheet Tomography” J. Mizrachi, A. Narasimhan, K. Umadevi Venkataraju, P. Osten. Society for Neuroscience Annual Meeting Poster Session, November 2018, San Diego, CA
  • “Automated Reconstruction Pipeline for Oblique Light Sheet Tomography” J. Mizrachi, A. Narasimhan, K. UmadeviVenkataraju, P. Osten. Society for Neuroscience Annual Meeting Poster Session, November 2017, Washington D.C.

Undergraduate Thesis:

Dust in the Winds of Proto-planetary Nebulae: RV Tauri Stars and SRd Variables (Research funded through $23,900 stipend and 7.3 hours of observation time awarded by NASA’s Sophia project following submission of original research proposal. PI and Mentor: Dr. Robert Gehrz, University of Minnesota)

Undergraduate Work:

  • Simultaneous Determination of Oxygen Partial Pressure and Temperature of Perfluorohexyloctane with 16.4 Tesla Magnetic Resonance Spectroscopy (MRS) (Research funded through University stipend.  Published on 20-Apr-2013 in the University of Minnesota Digital Conservancy.  Permanent URL: http://purl.umn.edu/151536)
  • Analysis of Global and Local Relaxations of Perfluorohexyloctane with 16 Tesla MRI to Obtain Oxidation of Islet-cell Grafts In-Vivo (Research funded through University stipend.)
  • NOvA Neutrino Project, 08/2012 – 03/2013 (PI: Prof. Kenneth Heller; built modules for the detection of the identity of Neutrinos, specifically to study the oscillations of electron Neutrinos to order their masses and determine the mixing between Tau and Muon Neutrinos.  Also worked to detect Neutrinos from Supernovae in our galaxy in the hope of furthering our understanding of the Universe and the Big Bang)